PAC1 receptor (pacr_human)
FAMILY
Class B1 (Secretin) Peptide receptors VIP and PACAP receptors PAC1 receptor
GENE
ADCYAP1R1
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP type I receptor, PACAP-R-1, PACAP-R1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
G
|
V
|
V
|
H
|
V
|
S
|
L
|
A
|
10 |
A
|
L
|
L
|
L
|
L
|
P
|
M
|
A
|
P
|
A
|
20 |
M
|
H
|
S
|
D
|
C
|
I
|
F
|
K
|
K
|
E
|
30 |
Q
|
A
|
M
|
C
|
L
|
E
|
K
|
I
|
Q
|
R
|
40 |
A
|
N
|
E
|
L
|
M
|
G
|
F
|
N
|
D
|
S
|
50 |
S
|
P
|
G
|
C
|
P
|
G
|
M
|
W
|
D
|
N
|
60 |
I
|
T
|
C
|
W
|
K
|
P
|
A
|
H
|
V
|
G
|
70 |
E
|
M
|
V
|
L
|
V
|
S
|
C
|
P
|
E
|
L
|
80 |
F
|
R
|
I
|
F
|
N
|
P
|
D
|
Q
|
V
|
W
|
90 |
E
|
T
|
E
|
T
|
I
|
G
|
E
|
S
|
D
|
F
|
100 |
G
|
D
|
S
|
N
|
S
|
L
|
D
|
L
|
S
|
D
|
110 |
M
|
G
|
V
|
V
|
S
|
R
|
N
|
C
|
T
|
E
|
120 |
D
|
G
|
W
|
S
|
E
|
P
|
F
|
P
|
H
|
Y
|
130 |
F
|
D
|
A
|
C
|
G
|
F
|
D
|
E
|
Y
|
E
|
140 |
TM1 | |||||||||
S
|
E
|
T
|
G
|
D
|
Q
|
D
|
Y
|
Y
|
Y
|
150 |
L
|
S
|
V
|
K
|
A
|
L
|
Y
|
T
|
V
|
G
|
160 |
Y
|
S
|
T
|
S
|
L
|
V
|
T
|
L
|
T
|
T
|
170 |
A
|
M
|
V
|
I
|
L
|
C
|
R
|
F
|
R
|
K
|
180 |
ICL1 | TM2 | ||||||||
L
|
H
|
C
|
T
|
R
|
N
|
F
|
I
|
H
|
M
|
190 |
N
|
L
|
F
|
V
|
S
|
F
|
M
|
L
|
R
|
A
|
200 |
I
|
S
|
V
|
F
|
I
|
K
|
D
|
W
|
I
|
L
|
210 |
ECL1 | |||||||||
Y
|
A
|
E
|
Q
|
D
|
S
|
N
|
H
|
C
|
F
|
220 |
TM3 | |||||||||
I
|
S
|
T
|
V
|
E
|
C
|
K
|
A
|
V
|
M
|
230 |
V
|
F
|
F
|
H
|
Y
|
C
|
V
|
V
|
S
|
N
|
240 |
Y
|
F
|
W
|
L
|
F
|
I
|
E
|
G
|
L
|
Y
|
250 |
L
|
F
|
T
|
L
|
L
|
V
|
E
|
T
|
F
|
F
|
260 |
ICL2 | TM4 | ||||||||
P
|
E
|
R
|
R
|
Y
|
F
|
Y
|
W
|
Y
|
T
|
270 |
I
|
I
|
G
|
W
|
G
|
T
|
P
|
T
|
V
|
C
|
280 |
V
|
T
|
V
|
W
|
A
|
T
|
L
|
R
|
L
|
Y
|
290 |
ECL2 | |||||||||
F
|
D
|
D
|
T
|
G
|
C
|
W
|
D
|
M
|
N
|
300 |
TM5 | |||||||||
D
|
S
|
T
|
A
|
L
|
W
|
W
|
V
|
I
|
K
|
310 |
G
|
P
|
V
|
V
|
G
|
S
|
I
|
M
|
V
|
N
|
320 |
F
|
V
|
L
|
F
|
I
|
G
|
I
|
I
|
V
|
I
|
330 |
ICL3 | |||||||||
L
|
V
|
Q
|
K
|
L
|
Q
|
S
|
P
|
D
|
M
|
340 |
TM6 | |||||||||
G
|
G
|
N
|
E
|
S
|
S
|
I
|
Y
|
L
|
R
|
350 |
L
|
A
|
R
|
S
|
T
|
L
|
L
|
L
|
I
|
P
|
360 |
L
|
F
|
G
|
I
|
H
|
Y
|
T
|
V
|
F
|
A
|
370 |
ECL3 | TM7 | ||||||||
F
|
S
|
P
|
E
|
N
|
V
|
S
|
K
|
R
|
E
|
380 |
R
|
L
|
V
|
F
|
E
|
L
|
G
|
L
|
G
|
S
|
390 |
F
|
Q
|
G
|
F
|
V
|
V
|
A
|
V
|
L
|
Y
|
400 |
H8 | |||||||||
C
|
F
|
L
|
N
|
G
|
E
|
V
|
Q
|
A
|
E
|
410 |
I
|
K
|
R
|
K
|
W
|
R
|
S
|
W
|
K
|
V
|
420 |
N
|
R
|
Y
|
F
|
A
|
V
|
D
|
F
|
K
|
H
|
430 |
C-term | |||||||||
R
|
H
|
P
|
S
|
L
|
A
|
S
|
S
|
G
|
V
|
440 |
N
|
G
|
G
|
T
|
Q
|
L
|
S
|
I
|
L
|
S
|
450 |
K
|
S
|
S
|
S
|
Q
|
I
|
R
|
M
|
S
|
G
|
460 |
L
|
P
|
A
|
D
|
N
|
L
|
A
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PACAP-27, PACAP-38, VIP, PHV, PHM, PHI